What is the clinical evidence from this study?

Study design: Other. Intervention: alpha-Human atrial natriuretic peptide (α-hANP). Primary outcome: Hydrolysis of PI-P2 induced by noradrenaline.

March 1, 1990British Journal of PharmacologyOpen Access

Inhibitory action of α‐human atrial natriuretic peptide on noradrenaline‐induced synthesis of myo‐inositol 1,4,5‐trisphosphate in the smooth muscle cells of rabbit aorta

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Key result

α-Human atrial natriuretic peptide consistently inhibited the hydrolysis of PI-P2 induced by noradrenaline in rabbit aorta smooth muscle cells.

Population

Smooth muscle cells of rabbit aorta (with or without vascular endothelium)

Design

Preclinical

Authors

JKJunko KajikuriNagoya City University HKHirosi KuriyamaSeinan Jo Gakuin University

Discussion

Member takes

Implication

Hypothesis-generating for ANP effects on vascular signaling; human studies needed before any clinical consideration.

Structured PICO

Population

Smooth muscle cells of rabbit aorta (with or without vascular endothelium)

Intervention

alpha-Human atrial natriuretic peptide (alpha-hANP; 0.1 microM) and other pharmacological agents (noradrenaline, acetylcholine, prazosin, db-cyclic GMP, db-cyclic AMP)

Outcome

Synthesis of myo-inositol 1,4,5-trisphosphate (IP3) and cyclic GMP, and hydrolysis of phosphatidylinositol 4,5-bisphosphate (PI-P2)surrogate

In rabbit aortic smooth muscle cells, alpha-hANP inhibits noradrenaline-induced IP3 synthesis via the alpha-hANP-guanylate cyclase process at the sarcolemma.

Cite This Study

Kajikuri et al. (1990) studied this question. alpha-Human atrial natriuretic peptide (α-hANP) was evaluated on Hydrolysis of PI-P2 induced by noradrenaline. α-Human atrial natriuretic peptide consistently inhibited the hydrolysis of PI-P2 induced by noradrenaline in rabbit aorta smooth muscle cells.

synapsesocial.com/papers/6a938805213a779dfe720423 https://doi.org/10.1111/j.1476-5381.1990.tb12964.x

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Inhibitory action of α‐human atrial natriuretic peptide on noradrenaline‐induced synthesis of myo‐inositol 1,4,5‐trisphosphate in the smooth muscle cells of rabbit aorta

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inhibitory action of α‐human atrial natriuretic peptide on noradrenaline‐induced synthesis of myo‐inositol 1,4,5‐trisphosphate in the smooth muscle cells of rabbit aorta

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider