Population
Cultured thoracic aorta smooth muscle cells
Comparison
Atrial natriuretic peptide (ANP) vs Unstimulated state / Angiotensin II
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether these phospholipase pathways mediate ANP effects in vivo.
ANP exerts stimulatory effects on phosphoinositol lipid metabolism via phospholipase C and phospholipase A2 in cultured vascular smooth muscle cells, suggesting these second-messenger cascades are involved in its physiological response.
Resink et al. (1988) studied this question.
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