ANP stimulates cGMP production and specific protein phosphorylation (including phospholamban) via cGMP-dependent protein kinase in smooth muscle cells, suggesting a mechanism for ANP-dependent relaxation.
No takes yet. Share an insight, caveat, or question.
ANP-cGMP-PKG signaling may mediate vascular relaxation in smooth muscle; leaves open translation to human cardiovascular therapies.
Brookes et al. (1989) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: