Why the study?
Does ANF elicit phosphorylation of PDE5 in vascular smooth muscle cells?
Does ANF elicit phosphorylation of PDE5 in vascular smooth muscle cells?
This study demonstrates for the first time the phosphorylation of PDE5 in intact vascular smooth muscle cells in response to ANF, suggesting a physiological role in smooth muscle regulation.
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ANF-PDE5 phosphorylation in VSMC remains preclinical; leaves open its role in vascular regulation pending in vivo confirmation.
Wyatt et al. (1998) studied this question.
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