Population
Cultured bovine pulmonary artery endothelial (CPAE) cell line
Comparison
Treatment with APIII, API, M&B 22948, or… vs Untreated cells or alternative treatments
Design
Preclinical
Follow-up
24 hours
Authors
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cGMP may down-regulate ANP clearance receptors in pulmonary endothelial cells; leaves open its role in modulating natriuretic peptide signaling in vivo.
In cultured bovine pulmonary artery endothelial cells, cGMP regulates ANP-binding sites and preferentially down-regulates the clearance (C) receptor.
Kato et al. (1991) studied this question.
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