Key result
Atrial natriuretic peptide (ANP) and C-ANP 4-23 inhibited the synthesis of endothelin-1 proteins by at least 50% and secretion by up to 55% in cultured bovine aortic endothelial cells.
Population
Cultured bovine aortic endothelial cells (BAEC)
Design
Preclinical
Authors
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Should not change clinical practice; leaves open ANP-ET-1 interactions in human vascular disease.
ANP inhibits ET-1 protein production and secretion in endothelial cells via the C receptor, highlighting a novel regulatory interaction in the vasculature.
Hu et al. (1992) studied Cultured bovine aortic endothelial cells (in vitro). Atrial natriuretic peptide (ANP) and C-ANP 4-23 was evaluated on ET-1 transcription, production, and secretion. Atrial natriuretic peptide (ANP) and C-ANP 4-23 inhibited the synthesis of endothelin-1 proteins by at least 50% and secretion by up to 55% in cultured bovine aortic endothelial cells.
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