Role of cyclic GMP in atrial‐natriuretic‐peptide stimulation of erythrocyte Na⁺/H⁺ exchange

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Population

Human erythrocytes

Design

Preclinical

Authors

Discussion

Should not yet change practice; leaves open ANP-cGMP effects on erythrocyte Na+/H+ exchange for in vivo validation.

Population

Human erythrocytes

Intervention

Human atrial natriuretic peptide (ANP) fragments (ANP-III, ANP-II), M&B 22,948, 8-Br-cGMP, and dibutyryl-cGMP

Outcome

Na+/H+ exchange and intraerythrocyte cGMP concentrationsurrogate

ANP stimulates Na+/H+ exchange in human erythrocytes via a cGMP-mediated pathway, demonstrating specific ANP receptor-like sensitivity.

Petrov et al. (1994) studied this question.

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