Key result
PMA attenuated ANP-stimulated cGMP production in a time- and dose-dependent manner, while ionomycin attenuated it only in the absence of MIX in cultured rat mesangial cells.
Population
Cultured rat mesangial cells prepared from isolated glomeruli of Sprague Dawley rats
Comparison
PMA and ionomycin vs alpha PDD or untreated control
Design
Preclinical
Authors
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PMA and ionomycin differentially modulate ANP-cGMP signaling in rat mesangial cells; leaves open PKC/Ca2+ roles in glomerular function.
PMA and ionomycin inhibit ANP-stimulated cGMP production in rat mesangial cells via distinct mechanisms involving PKC and cyclic nucleotide phosphodiesterase, respectively.
Akai et al. (1996) studied this question. PMA and Ionomycin vs. alpha PDD or absence of MIX was evaluated on ANP stimulated cGMP production. PMA attenuated ANP-stimulated cGMP production in a time- and dose-dependent manner, while ionomycin attenuated it only in the absence of MIX in cultured rat mesangial cells.
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