Why the study?
Do different vasodilators exert differential effects on forearm versus calf vessels in volunteers?
Do different vasodilators exert differential effects on forearm versus calf vessels in volunteers?
Vascular responses to vasodilators differ between the forearm and calf, indicating that the response in one limb is not representative of the whole circulation and depends on the vascular area and dose.
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Forearm and calf vessels respond differently to vasodilators; challenges assumption that single-limb data represent systemic circulation in research or practice.
Because the literature comparing the effects of vasodilators on forearm and calf vessels is very scarce, the authors compared different vasodilators used in cardiovascular medicine in a group of volunteers. The peripheral effects were measured in the sitting position by plethysmography at the calf and at the forearm. At the forearm, comparable dilator effects were seen in arteries and veins. At the calf there was a trend for arterial flow to decrease as venous capacitance increased. Vascular response seen in one limb was not representative of the whole circulation. The changes observed were dependent not only on the vascular area investigated but also on the dose used.
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Colardyn et al. (1990) studied this question.
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