April 7, 2021Nature CommunicationsOpen Access

Myofibril and mitochondria morphogenesis are coordinated by a mechanical feedback mechanism in muscle

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Why the study?

Mechanisms coordinating mitochondria with sarcomere morphogenesis across specialised muscle types remain elusive.

Population

Drosophila muscles

Comparison

Increased mitochondrial fusion during myofibril assembly vs baseline

Design

Preclinical experimental study

Authors

JAJerome AvellanedaLiving Systems (United States)CRClement RodierCentre National de la Recherche Scientifique FDFabrice DaianAix-Marseille Université

Discussion

Member takes

Implication

Highlights mitochondrial dynamics in Drosophila muscle patterning; leaves open relevance to vertebrate striated muscle.

Structured PICO

Population

Drosophila muscles (flight muscles and cross-striated leg muscles)

Intervention

Manipulation of mitochondrial dynamics (increased mitochondrial fusion during myofibril assembly)

Comparator

Normal mitochondrial dynamics / wild-type

Outcome

Mitochondrial intercalation and myofibril architecturesurrogate

Demonstrates a biomechanical feedback mechanism downstream of spalt that synchronizes mitochondria with myofibril morphogenesis in Drosophila muscles.

Cite This Study

Avellaneda et al. (2021) studied this question.

synapsesocial.com/papers/6a83f9db5dc7077fe9c595d2 https://doi.org/10.1038/s41467-021-22058-7

View Full Paper

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Myofibril and mitochondria morphogenesis are coordinated by a mechanical feedback mechanism in muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Myofibril and mitochondria morphogenesis are coordinated by a mechanical feedback mechanism in muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider