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March 1, 1981Cardiovascular Research

Reduction in vulnerability to ventricular fibrillation by bromocriptine, a dopamine agonist

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Why the study?

Does bromocriptine increase the ventricular fibrillation threshold in anaesthetised dogs?

Population

Anaesthetised dogs (nonischaemic canine ventricle model)

Comparison

Bromocriptine (dopamine agonist) vs Baseline and pretreatment with dopamine…

Design

Preclinical

Authors

RFRodney H. FalkHeart Failure & TransplantRDR DESILVABrigham and Women's HospitalBLBernard LownElectrophysiology

Discussion

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Implication

No immediate clinical implications; leaves open dopaminergic modulation of VF threshold as a hypothesis for further study.

Structured PICO

Does bromocriptine increase the ventricular fibrillation threshold in anaesthetised dogs?

P
Population
Anaesthetised dogs (nonischaemic canine ventricle model)
I
Intervention
Bromocriptine (dopamine agonist)
C
Comparator
Baseline and pretreatment with dopamine antagonists (haloperidol or domperidone)
O
Outcome
Ventricular fibrillation (VF) thresholdsurrogate

Bromocriptine reduces vulnerability to ventricular fibrillation in nonischaemic canine ventricles, likely mediated by peripheral presynaptic stimulation of dopaminergic receptors.

Cite This Study

Falk et al. (1981) studied this question.

synapsesocial.com/papers/6a83fa7a53408ed95e4d92c8https://doi.org/10.1093/cvr/15.3.175
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Effect of Cocaine on Ventricular Fibrillation Threshold in the Normal Canine Heart1996 · 24 citations
  2. 2Effect of posterior hypothalamic stimulation on ventricular fibrillation threshold1975 · 118 citations
  3. 3Failure of Beta-Adrenergic Blockade to Alter Ventricular Fibrillation Threshold in the Dog1966 · 22 citations
  4. 4ON THE RELATIONSHIP OF CATECHOLAMINES AND THYROID ACTIVITY TO VENTRICULAR FIBRILLATION DURING HYPOTHERMIA IN DOGS1963 · 1 citations
  5. 5ON THE RELATIONSHIP OF CATECHOLAMINES AND THYROID ACTIVITY TO VENTRICULAR FIBRILLATION DURING HYPOTHERMIA IN DOGS1963 · 12 citations