What question did this study set out to answer?

To determine whether endogenous biosynthesis of thromboxane and prostacyclin increases and correlates with disease progression in two distinct murine models of atherosclerosis.

December 1, 2000Blood

Endogenous biosynthesis of thromboxane and prostacyclin in 2 distinct murine models of atherosclerosis

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Authors

DPDomenico PraticòTemple University TCTillmann CyrusWashington University in St. Louis HLHongwei LiArmy Medical University

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Implication

Increased eicosanoid metabolites in atherosclerotic mice support hypothesis generation; leaves open their causal role and clinical relevance in humans.

Key Points

To determine whether endogenous biosynthesis of thromboxane and prostacyclin increases and correlates with disease progression in two distinct murine models of atherosclerosis.
Measured urinary metabolites of thromboxane (2,3-dinor thromboxane B2) and prostacyclin (2,3-dinor-6-keto prostaglandin F1alpha) in apolipoprotein E-deficient mice on chow diet and low-density lipoprotein receptor-deficient mice on chow or Western diets.
Quantified atherosclerotic lesion areas using en face analysis and evaluated the impact of aspirin administration on platelet aggregation and eicosanoid excretion.
Urinary excretion of both thromboxane and prostacyclin metabolites increased in chow-fed apoE-deficient mice and Western diet-fed LDLR-deficient mice, but remained unchanged in chow-fed LDLR-deficient mice.
Aspirin treatment effectively suppressed ex vivo platelet aggregation, reduced serum thromboxane B2 and urinary 2,3-dinor thromboxane B2, and significantly decreased urinary 2,3-dinor-6-keto prostaglandin F1alpha excretion.

Cite This Study

Praticò et al. (2000) studied this question.

synapsesocial.com/papers/6a83fa9b82dd948707b068db https://doi.org/10.1182/blood.v96.12.3823

Topics

Dual antiplatelet therapy

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Implication

Increased eicosanoid metabolites in atherosclerotic mice support hypothesis generation; leaves open their causal role and clinical relevance in humans.

Endogenous biosynthesis of thromboxane and prostacyclin in 2 distinct murine models of atherosclerosis

Discussion

Member takes

Implication

Key Points

Cite This Study

Topics

Endogenous biosynthesis of thromboxane and prostacyclin in 2 distinct murine models of atherosclerosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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