The role of demographic features, pathologic subtype and classifications on prognosis in patients with Rhabdomyosarcoma referred to Iran Cancer Institute

Background: Rhabdomyosarcoma is a rare malignant so� �ssue sarcoma and the most common sarcoma of childhood. The purpose of this study was to invesgate the distribuon of age and sex of paents, pathological subtypes and to determine the role of staging and classificaon of RMS on treatment outcome. Materials and Methods: This retrospecve study included paents who diagnosed with RMS in Cancer Instute between 2006 and 2013. We used the Kaplan Meier and life table methods to esmate survival rate. STATA stascal soware ver. 11.2 was used for stascal analyses. Results: Thirty paents with a mean age of 15.1 years (±SD =18.1) were evaluated.66.6 Percent were males. Median follow-up for survivors was 57.3 months (±SD=32.4). Survival rates of paents were as follows: 6 months (94%), 1 year (87%), 3 years (69%), and 5 years (50%). The pathology review classified of tumors as botryoid (6.7%), spindle cell (6.7%), embryonal (40%), alveolar (33.3%) and undifferenated (13.3%). 3 years survival for paents with internaonal classificaon III (alveolar and undifferenated) was 70%, Internaonal classificaon II (embryonal) was 67%. Due to small sample size, we can't report 3 years survival for internaonal classificaon I (botryoid and spindle cell). Conclusion: Our results support early age of onset (>50% of RMS cases are diagnosed before age 10 years). Age of diagnosis oen gives key facts about clinical behavior and has a noceable effect on 5 year survival; it is a prognosc factor in RMS. Disease extent as well as age and histology affect survival.