January 9, 2017PlateletsOpen Access

The use of regression analysis in determining reference intervals for low hematocrit and thrombocyte count in multiple electrode aggregometry and platelet function analyzer 100 testing of platelet function

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Population

Volunteer whole blood subjected to dilution methods to achieve low ranges of platelet count and hematocrit…

Comparison

Multiple electrode aggregometry and platelet… vs Originally established reference intervals

Design

Other

Authors

GKGerhardus J.A.J.M. KuiperApple (Israel)RHRik HoubenMaastricht University RWRick J. H. WetzelsMaastricht University Medical Centre

Discussion

Member takes

Implication

MEA and PFA-100 require cautious interpretation in thrombocytopenia or anemia; Level 4 data leaves open adjusted reference intervals.

Structured PICO

Population

Volunteer whole blood subjected to dilution methods to achieve low ranges of platelet count and hematocrit levels

Intervention

Multiple electrode aggregometry (MEA) and platelet function analyzer 100 (PFA-100) testing

Comparator

Originally established reference intervals

Outcome

95% reference intervals for platelet function at low ranges of platelet count and hematocrit levelssurrogate

Regression analysis can establish reference intervals for platelet function testing using MEA and PFA-100 in conditions of anemia and thrombocytopenia.

Limitations

Coefficients of determination of PFA-100 were poor
Some variance remained unexplained

Cite This Study

Kuiper et al. (2017) studied this question.

synapsesocial.com/papers/6a83faf3a3cef8348e997e7a https://doi.org/10.1080/09537104.2016.1257782

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The use of regression analysis in determining reference intervals for low hematocrit and thrombocyte count in multiple electrode aggregometry and platelet function analyzer 100 testing of platelet function

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

The use of regression analysis in determining reference intervals for low hematocrit and thrombocyte count in multiple electrode aggregometry and platelet function analyzer 100 testing of platelet function

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider