What question did this study set out to answer?

Investigate the cellular mechanisms causing adverse extracellular matrix and fibrotic tissue formation around transplanted human embryonic stem cell-derived cardiomyocytes.

October 21, 2009Cellular and Molecular Life SciencesOpen Access

Extracellular matrix formation after transplantation of human embryonic stem cell-derived cardiomyocytes

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Investigate the cellular mechanisms causing adverse extracellular matrix and fibrotic tissue formation around transplanted human embryonic stem cell-derived cardiomyocytes.
Assessed in vitro extracellular matrix protein deposition and integrin receptor expression in human embryonic stem cell-derived cardiomyocytes (hESC-CM).
Transplanted hESC-CM alone or co-transplanted them with hESC-derived endothelial cells and cardiac progenitors into mouse hearts, monitoring graft integration for at least 24 weeks.
Transplanted hESC-CM actively expressed corresponding integrins and continued secreting fibronectin, collagen IV, and collagen XVIII in mouse myocardium.
Co-transplantation with hESC-derived endothelial cells led to the formation of functional capillaries, enabling hESC-CM to survive and mature in vivo for at least 24 weeks.

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Implication

Preclinical study reveals that transplanted stem cell-derived cardiomyocytes secrete extracellular matrix in mouse hearts, highlighting strategies to reduce fibrosis and improve engraftment.

Cite This Study

Laake et al. (2009) studied this question.

synapsesocial.com/papers/6a83fbaf4d653d38678dee4b https://doi.org/10.1007/s00018-009-0179-z

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Implication

Preclinical study reveals that transplanted stem cell-derived cardiomyocytes secrete extracellular matrix in mouse hearts, highlighting strategies to reduce fibrosis and improve engraftment.

Extracellular matrix formation after transplantation of human embryonic stem cell-derived cardiomyocytes

Key Points

Discussion

Implication

Cite This Study

Extracellular matrix formation after transplantation of human embryonic stem cell-derived cardiomyocytes

Key Points

Discussion

Implication

Cite This Study

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