Why the study?
Does combination therapy of losartan and pioglitazone reduce blood pressure and improve vascular lesions in metabolic syndrome rats?
Population
Metabolic syndrome (MS) rats induced by a high-fat, high-sodium diet and 20% sucrose solution
Comparison
Combination therapy of losartan and pioglitazone… vs Losartan monotherapy, pioglitazone monotherapy…
Design
Preclinical
Follow-up
8 weeks
Authors
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May support preclinical synergy for BP lowering in metabolic syndrome; leaves open translation to human therapy.
Does combination therapy of losartan and pioglitazone reduce blood pressure and improve vascular lesions in metabolic syndrome rats?
The combination of losartan and pioglitazone synergistically lowers blood pressure and improves endothelial dysfunction in a rat model of metabolic syndrome.
Kong et al. (2013) studied this question.
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