Population
Phenylephrine (PE) precontracted isolated carotid arteries from the rabbit
Comparison
Acetylcholine and calcium ionophore A23187 in… vs Control conditions
Design
Preclinical
Authors
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Identifies cytochrome P450-KCa pathway for EDHF in rabbit arteries; leaves open relevance to human endothelial dysfunction.
In rabbit carotid arteries, acetylcholine induces the release of both NO and EDHF, with EDHF-mediated relaxation involving a cytochrome P450 pathway and KCa channels.
Dong et al. (1997) studied this question.
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