Key result
Acetylcholine-induced nitric oxide release fully accounts for endothelium-dependent relaxation and hyperpolarization in the rabbit carotid artery, despite partial resistance to NOS inhibitors.
Nitric oxide, rather than another factor, fully accounts for endothelium-dependent relaxation and hyperpolarization in the rabbit carotid artery.
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Reinforces NO as sole mediator in rabbit carotid arteries; leaves open species-specific or disease-related roles for other factors in humans.
Cohen et al. (1997) studied Endothelium-dependent relaxation and hyperpolarization. Acetylcholine and NO synthase inhibitors (L-NAME, L-NNA) was evaluated on Endothelium-dependent relaxation, hyperpolarization, and NO release. Acetylcholine-induced nitric oxide release fully accounts for endothelium-dependent relaxation and hyperpolarization in the rabbit carotid artery, despite partial resistance to NOS inhibitors.
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