Why the study?
Although AMI patients with low BMI exhibit worse clinical outcomes than obese patients, no prospective nationwide study had assessed the effect of BMI on clinical outcomes in this population.
Does low body mass index worsen clinical outcomes in Japanese patients with acute myocardial infarction?
Does low body mass index worsen clinical outcomes in Japanese patients with acute myocardial infarction?
Low BMI is an independent predictor of worse clinical outcomes, including all-cause mortality, in Japanese patients with acute myocardial infarction despite having fewer traditional coronary risk factors.
Low BMI may flag higher mortality risk in Japanese AMI; hypothesis-generating for risk stratification, should not yet change practice.
BACKGROUND: Acute myocardial infarction (AMI) patients with low body mass index (BMI) exhibit worse clinical outcomes than obese patients; however, to our knowledge, no prospective, nationwide study has assessed the effect of BMI on the clinical outcomes of AMI patients. METHODS AND RESULTS: ≤BMI, n=144). The primary endpoint was all-cause death, and the secondary endpoint was a composite of cardiovascular death, non-fatal myocardial infarction (MI), and non-fatal stroke. The median follow-up period was 358 days. Q1 patients were older and had lower prevalence of coronary risk factors. Q1 patients also had higher all-cause mortality and higher incidence of secondary endpoints than normal-weight or obese AMI patients. Multivariate analysis showed that low BMI (Q1 group) was an independent predictor for primary endpoint. CONCLUSIONS: AMI patients with low BMI had fewer coronary risk factors but worse clinical outcomes than normal-weight or obese patients.
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A 2021 study studied this question.
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