Why the study?
Does the combination of halothane and quinidine depress cardiac conduction and prolong the QTc interval in pentobarbital-anesthetized dogs?
Population
Pentobarbital-anesthetized dogs (n=20) and cross-superfused Purkinje fibers from a second dog
Comparison
1% halothane, quinidine, or both vs Basal pentobarbital anesthesia
Design
Preclinical
Authors
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May warrant caution in canine anesthesia models; leaves open human perioperative relevance pending further study.
Does the combination of halothane and quinidine depress cardiac conduction and prolong the QTc interval in pentobarbital-anesthetized dogs?
The combination of halothane and therapeutic concentrations of quinidine can depress cardiac conduction and induce an acquired long QT syndrome with malignant ventricular arrhythmias in a canine model.
John D. Gallagher (1992) studied this question.
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