Why the study?
Does quinidine prevent inducible ventricular tachyarrhythmia better than quinine or saline in a canine model of ischemic injury?
Population
24 dogs with inducible sustained ventricular tachyarrhythmia late after ischemic injury
Comparison
Quinidine infusion vs Quinine infusion or saline infusion
Design
Preclinical, randomly assigned
Authors
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Hypothesis-generating for quinidine's refractoriness effects in ischemic VT; leaves open clinical translation.
Does quinidine prevent inducible ventricular tachyarrhythmia better than quinine or saline in a canine model of ischemic injury?
In a canine model of ventricular tachycardia, quinidine's antiarrhythmic efficacy is driven by its ability to prolong refractoriness rather than just conduction time.
Sheldon et al. (1990) studied this question.
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