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September 1, 1992Circulation ResearchOpen Access

Positive chronotropic responses induced by alpha 1-adrenergic stimulation of normal and "ischemic" Purkinje fibers have different receptor-effector coupling mechanisms.

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Population

Canine Purkinje fibers (normal and "ischemic" models)

Comparison

Alpha 1-adrenergic stimulation with various… vs Normal conditions versus ischemic conditions

Design

Preclinical

Authors

EAEvgeny P. AnyukhovskyVRVitalyi O. RybinANA. V. Nikashin

Discussion

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Overview

Alpha 1-adrenergic stimulation induces abnormal automaticity in ischemic canine Purkinje fibers via a WB 4101-sensitive receptor subtype and a PTX-sensitive G protein, differing from mechanisms in normal fibers.

Structured PICO

P
Population
Canine Purkinje fibers (normal and "ischemic" models)
I
Intervention
Alpha 1-adrenergic stimulation (phenylephrine) with various modulators (chloroethylclonidine, WB 4101, pertussis toxin, ryanodine)
C
Comparator
Normal conditions (control Tyrode's solution) versus ischemic conditions (ischemic superfusate with 10 mM KCl, 5 mM NaHCO3, Po2 10-25 mm Hg, pH 6.7)
O
Outcome
Incidence of abnormal automaticity and changes in normal automaticitysurrogate

Alpha 1-adrenergic stimulation induces abnormal automaticity in ischemic canine Purkinje fibers via a WB 4101-sensitive receptor subtype and a PTX-sensitive G protein, differing from mechanisms in normal fibers.

Cite This Study

Anyukhovsky et al. (1992) studied this question.

synapsesocial.com/papers/6a83fc67addadcf8413c21e1https://doi.org/10.1161/01.res.71.3.526
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