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June 1, 1991CirculationOpen Access

Abnormal automatic rhythms in ischemic Purkinje fibers are modulated by a specific alpha 1-adrenergic receptor subtype.

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Why the study?

Does blockade of specific alpha 1-adrenergic receptor subtypes modulate abnormal automatic rhythms in ischemic canine Purkinje fibers?

Population

Isolated canine Purkinje fibers undergoing simulated ischemia and reperfusion

Comparison

Alpha 1-adrenergic receptor blockers in the… vs Control situation

Design

Preclinical

Authors

EAEvgeny P. AnyukhovskyMRM R Rosen

Discussion

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Overview

Alpha1A-selective blockade merits exploration as an antiarrhythmic target in ischemia; hypothesis-generating in this animal model and leaves clinical translation open.

Structured PICO

Does blockade of specific alpha 1-adrenergic receptor subtypes modulate abnormal automatic rhythms in ischemic canine Purkinje fibers?

P
Population
Isolated canine Purkinje fibers undergoing simulated ischemia and reperfusion
I
Intervention
Alpha 1-adrenergic receptor blockers (chloroethylclonidine and WB 4101) in the presence of propranolol and phenylephrine
C
Comparator
Control situation (fibers not treated with phenylephrine or specific blockers)
O
Outcome
Incidence of abnormal automaticity and membrane potential changes during simulated ischemiasurrogate

Blockade of a specific alpha 1-adrenergic receptor subtype with WB 4101 prevents abnormal automaticity in ischemic canine Purkinje fibers, suggesting a potential mechanistic target for ischemia-induced arrhythmias.

Cite This Study

Anyukhovsky et al. (1991) studied this question.

synapsesocial.com/papers/6a20b37df778797513eb8966https://doi.org/10.1161/01.cir.83.6.2076
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