Population
Single voltage-clamped ventricular myocytes isolated from guinea pig hearts
Comparison
Intracellularly dialyzed inositol… vs Control conditions (baseline currents)
Design
Preclinical
Authors
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Animal evidence links IP3 to myocyte Ca2+ handling; leaves open relevance to human arrhythmias or heart failure.
Inositol 1,4,5-trisphosphate promotes Na-Ca exchange across the plasma membrane by releasing Ca2+ from the sarcoplasmic reticulum in cardiac myocytes.
Gilbert et al. (1991) studied this question.
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