Population
Murine models of heart failure; adult mice with tamoxifen-inducible and heart-specific disruption of Pdk1
Design
Preclinical
Authors
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Pdk1 disruption causes lethal HF in adult mice; hypothesis-generating for its role in human cardiomyopathy and beta-adrenergic signaling.
PDK1 plays a critical role in cardiac homeostasis in vivo by serving as a dual effector for cell survival and beta-adrenergic response.
Ito et al. (2009) studied this question.
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