Why the study?
Does aliskiren prevent cardiac dysfunction compared to benazeprilat or valsartan in a diabetic mouse model?
Population
Adult mice with diabetes induced by STZ (streptozotocin)
Comparison
Aliskiren via subcutaneous mini-pumps vs Benazeprilat, valsartan, or insulin via…
Design
Preclinical
Follow-up
10 weeks
Authors
Loading...
Preclinical mouse data do not inform RAS inhibitor selection in diabetes; leaves open whether renin inhibition differs from ACEI/ARB in patients.
Does aliskiren prevent cardiac dysfunction compared to benazeprilat or valsartan in a diabetic mouse model?
Renin inhibition provides similar protection against diabetic cardiomyopathy as ACE inhibitors and ARBs in a mouse model, though with subtle mechanistic differences.
Thomas et al. (2012) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: