Cyclosporine Nephrotoxicity

Editorials1 December 1983Cyclosporine NephrotoxicityWILLIAM M. BENNETT, M.D., JOSEPH P. PULLIAM, M.D.WILLIAM M. BENNETT, M.D., JOSEPH P. PULLIAM, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-6-851 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCyclosporine is a potent new immunosuppressive agent that selectively inhibits T-cell function, allowing survival of allografts without myelosuppression. Its use should minimize the many adverse effects of long-term steroid therapy. Although the long-term effects of cyclosporine on renal allograft longevity are not well documented, enthusiastic reports in the medical literature and lay press have led to an unprecedented anticipation by prospective allograft recipients, particularly patients with chronic renal failure receiving long-term dialysis. However, these reports have not sufficiently emphasized the nephrotoxicity that frequently accompanies cyclosporine therapy.Cyclosporine is a lipophilic molecule with a molecular weight of 1202 daltons. When the...References1. BEVERIDGE T. Pharmacokinetics and metabolism of cyclosporin A. In: WHITE DJ, ed. Cyclosporin A: Proceedings of the International Symposium, Cambridge. Amsterdam: Elsevier Biomedical Publishers; 1982:35-44. Google Scholar2. KAHANRIEDNEWBERGER BMJ. Pharmacokinetics of cyclosporine in human renal transplantation. Transplant Proc. 1983;15:446-53. Google Scholar3. WHITE D. Cyclosporin A: clinical pharmacology and therapeutic potential. Drugs. 1982;24:322-34. CrossrefMedlineGoogle Scholar4. KAHAN B. Meeting Report: the First International Congress on Cyclosporine: Houston, Texas: May 16-19, 1983. Dial Transplant. 1983;12:620-30. Google Scholar5. VON WILLEBRANDHAYRY EP. Cyclosporin-A deposits in renal allografts. Lancet. 1983;2:189-92. CrossrefMedlineGoogle Scholar6. 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SENNESAEL, M.D., ALAIN G. DUPONT, M.D., DIERIK L. VERBEELEN, M.D., L. VAN HAELST, M.D., Ph.D., LEENDERT C. PAUL, M.D., Ph.D.Cyclosporine: A review of drug monitoring problems and presentation of a simple, accurate liquid chromatographic procedure that solves these problemsCyclosporin and renal graft histology.Elective conversion from cyclosporine to azathioprine in recipients with stable renal function 6 months after kidney transplantationEffect of cyclosporine administration on renal hemodynamics in conscious ratsDIFFERENTIATION BETWEEN ALLOGRAFT REJECTION AND CYCLOSPORIN NEPHROTOXICITY IN RENAL-TRANSPLANT RECIPIENTSCyclosporine in Cardiac TransplantationCiclosporin in Autoimmune Diseases — Side Effects (with Emphasis on Renal Dysfunction) and Recommendations for UseINTERSTITIAL FIBROSIS IN RENAL ALLOGRAFTS IN PATIENTS TREATED WITH CYCLOSPORINCyclosporine-Associated Chronic NephropathyMechanisms of Drug NephrotoxicityNephrologie III 1 December 1983Volume 99, Issue 6Page: 851-854KeywordsImmunosuppressivesMedical dialysisRenal failureSteroid therapy Issue Published: 1 December 1983 PDF downloadLoading ...