What question did this study set out to answer?

To investigate the epidemiology, seroprevalence, and genomic characteristics of human herpesvirus 8 (HHV-8) across indigenous Brazilian Amerindian populations.

May 1, 2000The Journal of Infectious DiseasesOpen Access

Human Herpesvirus 8 in Brazilian Amerindians: A Hyperendemic Population with a New Subtype

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To investigate the epidemiology, seroprevalence, and genomic characteristics of human herpesvirus 8 (HHV-8) across indigenous Brazilian Amerindian populations.
Screened 781 Amerindians from diverse tribes for latent HHV-8 antibodies using an immunofluorescence assay (IFA).
Tested IFA-positive individuals for viral DNA in peripheral blood mononuclear cells (n=19) and saliva (n=16), followed by sequence analysis of the conserved ORF22 and K6 genes and the variable K1 gene.
Overall HHV-8 seroprevalence was 53% (n=781), rising progressively from 41% in children under 10 years of age to 65% in adults aged 30 years or older, independent of sex or language group.
Viral DNA was detected in 16% (3 of 19) of blood mononuclear cell samples and 6.25% (1 of 16) of saliva samples from seropositive individuals.
Variable K1 gene sequences shared only 70% to 75% identity with known strains, identifying a novel hyperendemic lineage (subtype E) circulating in the absence of reported Kaposi's sarcoma.

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Implication

Cross-sectional study reveals hyperendemic human herpesvirus 8 infection driven by a novel subtype in Brazilian Amerindians, suggesting early nonsexual transmission.

Cite This Study

Biggar et al. (2000) studied this question.

synapsesocial.com/papers/6a84032b121b098de683d258 https://doi.org/10.1086/315456

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Implication

Cross-sectional study reveals hyperendemic human herpesvirus 8 infection driven by a novel subtype in Brazilian Amerindians, suggesting early nonsexual transmission.

Human Herpesvirus 8 in Brazilian Amerindians: A Hyperendemic Population with a New Subtype

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Discussion

Implication

Cite This Study

Human Herpesvirus 8 in Brazilian Amerindians: A Hyperendemic Population with a New Subtype

Key Points

Discussion

Implication

Cite This Study

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