January 1, 2009Pharmacology

Regulators Involved in the Electrically Stimulated Response of Feline Esophageal Smooth Muscle

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Population

Feline distal esophageal smooth muscles

Design

Preclinical

Authors

SPSun Young ParkPusan National University SPSung Uk ParkChung-Ang University USUy Dong SohnChung-Ang University

Discussion

Member takes

Implication

Hypothesis-generating for G-protein/MLCK pathways in esophageal motility; leaves open human translation.

Structured PICO

Population

Feline distal esophageal smooth muscles

Intervention

Electrical field stimulation (EFS) and pharmacological agents (L-NAME, tetrodotoxin, atropine, ML-9, chelerythrine, aluminum fluoride, pertussis toxin, C3 exoenzyme, 4-AP)

Outcome

Muscle contractions (on-contraction and off-contraction) measured by isometric force transducersurrogate

Cholinergic nerves and nitric oxide are major intrinsic contributors to feline distal esophageal smooth muscle motility, mediated by external Ca2+, MLCK, and G proteins.

Cite This Study

Park et al. (2009) studied this question.

synapsesocial.com/papers/6a8403ace22b852b8ec51d6b https://doi.org/10.1159/000253876

View Full Paper

Ask AI

Bookmark

Regulators Involved in the Electrically Stimulated Response of Feline Esophageal Smooth Muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regulators Involved in the Electrically Stimulated Response of Feline Esophageal Smooth Muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider