Key result
Transmural field stimulation of human lower esophagus triggers postganglionic transmitter release acting on muscarinic receptors.
Population
Isolated smooth muscle strips representing longitudinal and circular muscle layers of the esophagogastric…
Design
Preclinical
Authors
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Refines models of esophageal neuromuscular control; leaves open in vivo relevance for motility disorders.
Transmural field stimulation of human lower esophagus muscle strips reveals distinct neurotransmitter responses in longitudinal versus circular muscle layers.
Tøttrup et al. (1990) studied this question. Transmural field stimulation was evaluated on Isometric tension (muscle contraction and relaxation). Transmural field stimulation of human lower esophagus longitudinal muscle causes postganglionic nerves to release transmitters acting on muscarinic receptors.
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