Why the study?
Does pharmacological removal of sympathetic inhibition and potentiation of tone restore alimentary-tract motility in patients with ileus?
Does pharmacological removal of sympathetic inhibition and potentiation of tone restore alimentary-tract motility in patients with ileus?
The paper proposes that ileus should be treated by removing sympathetic inhibition and potentiating tone, challenging the concept that the gut is paralyzed.
Challenges paralyzed-gut paradigm in ileus; hypothesis-generating from Level 5 cases and requires prospective trials.
The nature of ileus and the clinical problem it poses are discussed. A consideration of the previous multiplicity of treatments is presented. The concepts behind the present mode of treatment are outlined. This consists of removing the sympathetic inhibition of the alimentary tract in the condition and potentiating or supplementing tone. Case histories are presented to illustrate the use of the drugs suggested, and the indications for therapy are discussed. The mistaken concept that the gut is “paralysed” in ileus should be finally abandoned.
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Neely et al. (1971) studied this question.
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