Why the study?
The genetic etiology of LVNC in children is not completely understood, although up to 41% of cases are thought to be genetic.
Identifies a novel MYH 7 gene mutation associated with familial Left Ventricular Non Compaction, expanding the known genetic etiology of the disease.
Expands known genetic causes of familial LVNC; hypothesis-generating and should not yet change practice.
Left Ventricular Non Compaction (LVNC) is considered a unique cardiomyopathy according to the American Heart Association guidelines. The genetic ethology of LVNC in children is not completely understood although upto 41% of LVNC are thought to be genetic. We report a family with LVNC due to a novel mutation in the MYH 7 gene.
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Alawani et al. (2021) studied this question.
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