Bi-directional transcription proceeding from the intergenic region favors intramolecular recombination in polyomavirus DNA.
Supports bidirectional transcription in polyomavirus recombination; leaves open applicability to other viruses or antiviral strategies.
We show here that intramolecular homologous recombination in polyomavirus (Py) DNA depends upon discrete sequence elements of the viral regulatory region which are believed to regulate transcription initiation and exert little or no cis-control over replication. Either deleting the viral early promoter (EP) or inverting the viral late promoter (LP) strongly impairs viral DNA recombination under conditions allowing viral DNA replication to proceed undisturbed. These findings suggest that bi-directional transcription proceeding from the intergenic region favors intramolecular recombination.
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Nault et al. (1994) studied this question.
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