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Although typically associated with hypothermia, Osborn waves have been reported at normal body temperature across various conditions, prompting this description of a case in moderate COVID-19.
This case report demonstrates that Osborn waves can appear on the ECG of normothermic patients with COVID-19, potentially reflecting intramyocardial electrolyte imbalance or therapy effects.
May signal myocardial involvement in normothermic COVID-19; hypothesis-generating and requires validation before clinical adoption.
The classic Osborn wave in the form of characteristic changes at the depolarization end or ventricular repolarization beginning is more often associated with hypothermia (body temperature below 35,6° C). Some researchers have noticed Osborn wave at normal body temperature, various pathological conditions and diseases: hypercalcemia, myocardial ischemia, postoperative pericarditis, with central nervous system, etc. We presented a case report of a 72-year-old female inpatient with moderate COVID-19, confirmed by polymerase chain reaction, and 48% lung damage. Before admission to the hospital, electrocardiogram had no Osborn wave, which first appeared at admission. There was a significant increase in serum C-reactive protein and a moderate increase in serum biomarkers and no changes in intervals and segments on the electrocardiogram. The appearance of Osborn wave may be associated with intramyocardial electrolyte imbalance, a consequence of antiviral and antibacterial therapy that violate intraventricular conduction.
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Musin et al. (2021) studied this question.
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