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he use of an extracorporeal circuit in surgery requires adequate anticoagulation with heparin. At the termination of cardiopul-T monary bypass, a heparin antagonist is usually administered to facilitate hemostasis [6, 81. Protamine sulfate, or more recently protamine chloride, has been given to promote normal coagulation [2,
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Goldman et al. (1969) studied this question.
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