January 1, 1986AJP Cell Physiology

Electrophysiological characterization of single pregnant rat myometrial cells in short-term primary culture

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Population

Smooth muscle cells isolated from the longitudinal layer of pregnant rat myometrium (18-19 days)

Design

Preclinical

Follow-up

up to 30 hours

Authors

PMPatrice MollardCentre National de la Recherche Scientifique JMJean MironneauCentre National de la Recherche Scientifique TAThierry AmédéeCentre National de la Recherche Scientifique

Discussion

Member takes

Implication

Characterizes Ca2+-dependent excitability in rat myometrium; leaves open translation to human labor or tocolysis.

Structured PICO

Population

Smooth muscle cells isolated from the longitudinal layer of pregnant rat myometrium (18-19 days)

Intervention

Electrophysiological characterization using intracellular microelectrode techniques and pharmacological agents (Ca2+-free solution, Mn2+, Co2+, D 600, tetrodotoxin, TEA, 4-AP)

Outcome

Electrophysiological properties including resting potential, action potential, membrane resistance, and capacitancesurrogate

This study characterizes the electrophysiological properties of isolated pregnant rat myometrial cells, demonstrating Ca2+-dependent action potentials.

Cite This Study

Mollard et al. (1986) studied this question.

synapsesocial.com/papers/6a8409df9cea0905630b9647 https://doi.org/10.1152/ajpcell.1986.250.1.c47

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Electrophysiological characterization of single pregnant rat myometrial cells in short-term primary culture

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Electrophysiological characterization of single pregnant rat myometrial cells in short-term primary culture

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider