Key result
In single smooth muscle cells from pregnant rat uterus, depolarizing pulses evoked TTX-sensitive fast Na+ currents and dihydropyridine-sensitive slow Ca2+ (L-type) currents.
Population
Single smooth muscle cells freshly isolated from the longitudinal layer of 18-day pregnant rat uterus
Design
Preclinical
Authors
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Preclinical rat cell data should not guide clinical practice; leaves open the role of these currents in human uterine function.
Identifies TTX-sensitive fast Na+ channels and dihydropyridine-sensitive slow Ca2+ channels as the major inward current generators in pregnant rat uterine smooth muscle cells.
Ohya et al. (1989) studied Pregnant rat uterus. Tetrodotoxin (TTX) and nifedipine was evaluated on Inward currents (fast and slow). In single smooth muscle cells from pregnant rat uterus, depolarizing pulses evoked TTX-sensitive fast Na+ currents and dihydropyridine-sensitive slow Ca2+ (L-type) currents.
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