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November 1, 1986The Journal of PhysiologyOpen Access

Inactivation of calcium channel current in rat uterine smooth muscle: evidence for calcium‐ and voltage‐mediated mechanisms.

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Population

Cs-loaded myometrial strips from pregnant rats

Design

Preclinical

Authors

KJK JmariCentre National de la Recherche ScientifiqueCMC. MironneauCentre National de la Recherche ScientifiqueJMJean MironneauCentre National de la Recherche Scientifique

Discussion

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Implication

Does not alter clinical practice; leaves open translation of dual Ca- and voltage-dependent inactivation to human myometrium.

Structured PICO

P
Population
Cs-loaded myometrial strips from pregnant rats
I
Intervention
Electrophysiological manipulation (depolarizing pulses, replacement of external Ca by Ba or Sr, addition of Co)
O
Outcome
Inactivation of Ca channel currentsurrogate

Demonstrates that calcium channel inactivation in rat uterine smooth muscle is governed by both calcium-dependent and voltage-dependent mechanisms.

Cite This Study

Jmari et al. (1986) studied this question.

synapsesocial.com/papers/6a8387c710f97e202011ab1fhttps://doi.org/10.1113/jphysiol.1986.sp016275
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of calcium ions on outward membrane currents in rat uterine smooth muscle.1980 · 62 citations
  2. 2Calcium-mediated inactivation of the calcium conductance in cesium-loaded frog heart cells.1984 · 144 citations
  3. 3Inactivation of calcium channel current in the calf cardiac Purkinje fiber. Evidence for voltage- and calcium-mediated mechanisms.1984 · 273 citations
  4. 4Currents carried by monovalent cations through calcium channels in mouse neoplastic B lymphocytes.1985 · 234 citations
  5. 5High selectivity of calcium channels in single dialysed heart cells of the guinea‐pig.1984 · 186 citations