October 5, 2004Circulation

In Situ Akt Phosphorylation in the Nucleus Tractus Solitarii Is Involved in Central Control of Blood Pressure and Heart Rate

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Population

8- and 16-week-old male Wistar-Kyoto (WKY) rats, urethane-anesthetized

Design

Preclinical

Authors

HHHsiao-Ning HuangNational Cheng Kung University PLPei‐Jung LuNational Cheng Kung University WLWan-Chen LoKaohsiung Veterans General Hospital

Discussion

Member takes

Implication

Supports NTS insulin-PI3K-Akt-NOS signaling in rat central BP/HR control; leaves open translation to human cardiovascular disease.

Structured PICO

Population

8- and 16-week-old male Wistar-Kyoto (WKY) rats, urethane-anesthetized

Intervention

Unilateral microinjection (60 nL) of insulin (100 IU/mL) into the nucleus tractus solitarii (NTS), with or without pretreatment with PI3K inhibitor LY294002 and NOS inhibitor L-NAME

Outcome

Cardiovascular response (depressor and bradycardic effects) and Akt phosphorylationsurrogate

The insulin-PI3K-Akt-NOS signaling pathway in the nucleus tractus solitarii plays a significant role in central blood pressure and heart rate regulation in rats.

Cite This Study

Huang et al. (2004) studied this question.

synapsesocial.com/papers/6a840a2d002ab1506fb29396 https://doi.org/10.1161/01.cir.0000145116.75657.2d

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In Situ Akt Phosphorylation in the Nucleus Tractus Solitarii Is Involved in Central Control of Blood Pressure and Heart Rate

Discussion

Member takes

Implication

Structured PICO

Cite This Study

In Situ Akt Phosphorylation in the Nucleus Tractus Solitarii Is Involved in Central Control of Blood Pressure and Heart Rate

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider