January 6, 2012British Journal of PharmacologyOpen Access

Renin activates PI3K‐Akt‐eNOS signalling through the angiotensin AT1and Mas receptors to modulate central blood pressure control in the nucleus tractus solitarii

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Why the study?

Does renin microinjected into the NTS modulate central blood pressure control through the PI3K-Akt-eNOS pathway in Wistar-Kyoto rats?

Population

Wistar-Kyoto rats

Comparison

Microinjection of renin into the nucleus tractus… vs Pretreatment with specific inhibitors (eNOS…

Design

Preclinical

Authors

WCWen‐Han ChengNational Yang Ming Chiao Tung University PLPei‐Jung LuNational Cheng Kung University MHMichael HsiaoKaohsiung Medical University

Discussion

Member takes

Implication

Supports NTS renin signaling in rat BP control via Gq-PI3K-Akt-eNOS; leaves open translation to human hypertension.

Structured PICO

Does renin microinjected into the NTS modulate central blood pressure control through the PI3K-Akt-eNOS pathway in Wistar-Kyoto rats?

Population

Wistar-Kyoto rats

Intervention

Microinjection of renin into the nucleus tractus solitarii (NTS)

Comparator

Pretreatment with specific inhibitors (eNOS inhibitor, Akt inhibitor IV, LY294002, GP antagonist-2A, lisinopril, losartan, valsartan, D-Ala7-Ang-(1-7)) versus no pretreatment

Outcome

Depressor responses (blood pressure changes) and NO productionsurrogate

Renin modulates central blood pressure in the NTS via AT1 and Mas receptor-mediated activation of the Gq-PI3K-Akt-eNOS signaling pathway.

Cite This Study

Cheng et al. (2012) studied this question.

synapsesocial.com/papers/6a8336cb3efdfb27564cda90 https://doi.org/10.1111/j.1476-5381.2012.01832.x

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Renin activates PI3K‐Akt‐eNOS signalling through the angiotensin AT1and Mas receptors to modulate central blood pressure control in the nucleus tractus solitarii

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Renin activates PI3K‐Akt‐eNOS signalling through the angiotensin AT1and Mas receptors to modulate central blood pressure control in the nucleus tractus solitarii

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider