Key result
2K1C and L-NAME models reduce vascular NPR-A and NPR-C expression in rats, but DOCA-salt increases it.
Population
Male Sprague-Dawley rats with experimental hypertension induced by two-kidney, one-clip, deoxycorticosterone…
Design
Preclinical
Authors
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Should not yet alter hypertension management; leaves open model-specific receptor regulation in human disease.
Vascular expression of natriuretic peptide receptors appears to be reciprocally regulated by local renin-angiotensin system activity in experimental rat models of hypertension.
Lee et al. (2002) studied Hypertension. 2K1C, DOCA-salt, and L-NAME hypertension models was evaluated on mRNA expression of NPR-A, NPR-C, ACE, and AT1 receptors, and particulate guanylyl cyclase activity. In experimental hypertensive rats, vascular expression of natriuretic peptide receptors A and C was decreased in 2K1C and L-NAME models but increased in the DOCA-salt model.
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