Why the study?
Uncontrolled blood levels of the chemotherapeutic agent 5-fluorouracil contribute to toxicity, and quercetin has anti-tumor and anti-inflammatory effects.
Does quercetin improve the pharmacokinetic profile and anti-tumor activity of 5-fluorouracil in preclinical models?
Population
HT-29 cell line, fibroblast cells, and rats
Comparison
Intraperitoneal quercetin (10 mg/kg) vs Tween for 14 days, followed by 5-FU (50 mg/kg) on day 15
Design
In vitro and animal pharmacokinetic study
Authors
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Quercetin may increase 5-FU exposure in animal models; leaves open clinical translation and requires human trials.
Does quercetin improve the pharmacokinetic profile and anti-tumor activity of 5-fluorouracil in preclinical models?
Quercetin synergistically enhances the pharmacokinetic parameters and anti-tumor activity of 5-fluorouracil in preclinical models, suggesting potential for reduced toxicity in cancer treatment.
Pirzaman et al. (2023) studied this question.
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