Why the study?
Do beta-blockers (esmolol) improve outcomes in patients with sepsis or septic shock?
Do beta-blockers (esmolol) improve outcomes in patients with sepsis or septic shock?
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Caution is warranted regarding the use of beta-blockers in sepsis until large multi-center trials confirm their safety and efficacy.
Recent promising findings indicate a possible benefit of β-blockade in septic patients. Ongoing trials on esmolol in septic shock are investigating its hemodynamic effects, focusing on heart rate control and echocardiographic changes, as well as potential anti-inflammatory effects. However, given the complex physiology of sepsis and pharmacological effects on β-blockade, large multi-center trials are essential before such a therapy may be applied safely.
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Maybauer et al. (2015) studied this question.
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