September 4, 1998FEBS LettersOpen Access

Activation of mitogen‐activated protein kinases (p38‐MAPKs, SAPKs/JNKs and ERKs) by adenosine in the perfused rat heart

View Full Paper

Ask AI

Bookmark

Population

Perfused rat hearts

Design

Preclinical

Follow-up

5 minutes

Authors

SHSyed E.A. Haq ACAngela ClerkHeart Failure / Cardiomyopathy PSPeter H. SugdenHeart Failure & Transplant

Discussion

Member takes

Implication

Adenosine activates cardiac MAPKs in rats; hypothesis-generating for preconditioning mechanisms, leaves open human relevance.

Structured PICO

Population

Perfused rat hearts

Intervention

Adenosine (concentrations ranging from 10-100 microM to 10 mM)

Outcome

Activation and phosphorylation of MAPK subfamilies (p38-MAPK, SAPKs/JNKs, ERKs)surrogate

Adenosine rapidly activates multiple MAPK subfamilies in the perfused rat heart, providing a potential mechanistic basis for adenosine-mediated ischaemic preconditioning.

Cite This Study

Haq et al. (1998) studied this question.

synapsesocial.com/papers/6a840d47002ab1506fb29464 https://doi.org/10.1016/s0014-5793(98)01000-x

View Full Paper

Ask AI

Bookmark

Activation of mitogen‐activated protein kinases (p38‐MAPKs, SAPKs/JNKs and ERKs) by adenosine in the perfused rat heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Activation of mitogen‐activated protein kinases (p38‐MAPKs, SAPKs/JNKs and ERKs) by adenosine in the perfused rat heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider