Why the study?
Peculiarities in the architecture and dynamics of viral RNA-dependent RNA polymerases raise fundamental questions about ribonucleotide access to their active site during RNA polymerization.
Design
Molecular modeling and molecular dynamics simulations
Authors
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Simulations of RdRp active-site access may guide antiviral design; leaves open translation to clinical efficacy.
Key points are not available for this paper at this time.
ouirane et al. (2019) studied this question.
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