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April 18, 2013Wiley Interdisciplinary Reviews - RNAOpen Access

RNA synthetic mechanisms employed by diverse families of RNA viruses

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Design

Review

Key result

High-resolution structures of viral RNA-dependent RNA polymerases and their cofactors provide a scientific platform for the rational design of antiviral agents.

Authors

SMSarah M. McDonald

Discussion

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Overview

Structure-guided antivirals remain untested clinically; leaves open targeted development for viral diseases.

PICO

P
Population
RNA virus infection

Understanding the structural and functional features of viral RNA-dependent RNA polymerases provides a foundation for designing targeted antiviral therapies.

Cite This Study

Sarah M. McDonald (2013) conducted a review in RNA virus infection. High-resolution structures of viral RNA-dependent RNA polymerases and their cofactors provide a scientific platform for the rational design of antiviral agents.

synapsesocial.com/papers/6a7ca0f5f108d7d7faba495dhttps://doi.org/10.1002/wrna.1164
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