Why the study?
A better knowledge of viral RNA-dependent RNA polymerase phosphorylation is expected to facilitate the design of future antiviral drugs targeting polymerase activity.
Design
Review
Key result
Phosphorylation of viral RNA-dependent RNA polymerases by host kinases regulates viral RNA synthesis and represents a potential target for the design of future antiviral drugs.
Authors
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RdRp phosphorylation may guide host-directed antivirals; leaves open efficacy in clinical infection models.
Understanding the regulation of viral RNA-dependent RNA polymerases by host kinase-mediated phosphorylation may guide the development of novel antiviral therapies.
Duflos et al. (2023) conducted a review in RNA virus infections. Phosphorylation of viral RNA-dependent RNA polymerases was evaluated. Phosphorylation of viral RNA-dependent RNA polymerases by host kinases regulates viral RNA synthesis and represents a potential target for the design of future antiviral drugs.