August 1, 2002Journal of Applied Physiology

Estradiol increases salt intake in female normotensive and hypertensive rats

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Population

24 ovariectomized female rats (12 spontaneously hypertensive rats [SHR] and 12 Wistar Kyoto [WKY] rats)

Comparison

Three progressively larger doses of… vs Sham implants

Design

Preclinical

Follow-up

Three 2-week periods with 10-day washouts

Authors

EKEric KensickiUniversity of Akron GDGail DunphyAkron Children's Hospital DEDaniel ElyUniversity of Akron

Discussion

Member takes

Implication

Does not support changes in human hypertension care; leaves open estradiol-sodium links for translational study.

Structured PICO

Population

24 ovariectomized female rats (12 spontaneously hypertensive rats [SHR] and 12 Wistar Kyoto [WKY] rats)

Intervention

Three progressively larger doses of beta-estradiol propionate (each dose lasting 2 weeks, with 10-day washout periods between doses)

Comparator

Sham implants

Outcome

Sodium intake (consumption of 0.0, 0.5, 1.0, and 1.5% NaCl solutions)surrogate

Estradiol levels are positively correlated with sodium intake in both normotensive and hypertensive female rats, with hypertensive rats exhibiting greater sodium consumption.

Cite This Study

Kensicki et al. (2002) studied this question.

synapsesocial.com/papers/6a841632002ab1506fb2972d https://doi.org/10.1152/japplphysiol.00554.2001

Topics

Hypertension management

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Estradiol increases salt intake in female normotensive and hypertensive rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Estradiol increases salt intake in female normotensive and hypertensive rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider