June 1, 1989AJP Endocrinology and Metabolism

Modification of glycosylation of renin in sodium-depleted and captopril-treated rats

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Population

Rats (in vivo and in vitro renal cortical slices)

Comparison

Sodium depletion and captopril treatment for 2… vs Control rats

Design

Preclinical

Follow-up

2 weeks

Authors

SKS. KimThe University of Osaka MHM HosoiBoston University MHMasahito HirumaKanto Gakuin University

Discussion

Member takes

Implication

Does not support clinical renin isoform monitoring; leaves open translation of rodent renin C predominance to human states.

Structured PICO

Population

Rats (in vivo and in vitro renal cortical slices)

Intervention

Sodium depletion and captopril treatment (40-60 mg.kg-1.day-1) for 2 weeks

Comparator

Control rats

Outcome

Plasma renin concentration and relative proportions of differently glycosylated forms of renin (renin A, B, and C)surrogate

Sodium depletion and captopril treatment in rats predominantly release renin C, which has the longest half-life, contributing to increased plasma renin concentration.

Cite This Study

Kim et al. (1989) studied this question.

synapsesocial.com/papers/6a841814cdf3a848bdbd841a https://doi.org/10.1152/ajpendo.1989.256.6.e798

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Modification of glycosylation of renin in sodium-depleted and captopril-treated rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Modification of glycosylation of renin in sodium-depleted and captopril-treated rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider