Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 1, 1986Hypertension

Modulation of kidney renin messenger RNA levels during experimentally induced hypertension.

View Full Paper
Ask AI
Bookmark
Share

Key result

Aorta coarctation or renal artery clipping transiently increased ischemic kidney renin mRNA 10- to 16-fold, which was insufficient to account for the 30- to 50-fold increase in plasma renin activity.

Population

Sprague-Dawley rats made hypertensive by either coarctation of the aorta between the two renal arteries or…

Comparison

Experimentally induced hypertension via… vs Sham-operated rats

Design

Preclinical

Follow-up

14 days

Authors

RMRobert Bruce MoffettW.E. Upjohn Institute for Employment ResearchRMRoss McGowanAmazon (United States)KGKenneth W. GrossRoswell Park Comprehensive Cancer Center

Discussion

Loading...

Member takes

Implication

Posttranslational renin mechanisms may predominate in experimental hypertension; leaves open dominant pathways and human relevance.

Key Points

  • To investigate the changes in kidney renin messenger RNA levels in response to experimentally induced hypertension.
  • Used Sprague-Dawley rats subjected to aortic coarctation and left renal artery clipping.
  • Measured kidney renin mRNA levels and correlated these with plasma renin activity over time.
  • In ischemic kidneys, renin mRNA increased 10-fold to 16-fold within the first 3 days post-coarctation.
  • The increase in kidney renin mRNA did not account for the 30-fold to 50-fold increase in plasma renin activity.
  • Tissue renin activity only doubled in ischemic kidneys, indicating other factors also regulate plasma renin levels.

Structured PICO

P
Population
Sprague-Dawley rats made hypertensive by either coarctation of the aorta between the two renal arteries or clipping of the left renal artery
I
Intervention
Experimentally induced hypertension via coarctation of the aorta or clipping of the left renal artery
C
Comparator
Sham-operated rats
O
Outcome
Changes in kidney renin messenger RNA (mRNA) levels relative to changes for tissue and plasma renin activitysurrogate

In experimental hypertension models, transient increases in kidney renin mRNA are insufficient to explain the massive increases in plasma renin activity, suggesting posttranslational processing or release mechanisms are key contributors.

Cite This Study

Moffett et al. (1986) studied Experimentally induced hypertension. Coarctation of the aorta or clipping of the left renal artery vs. Sham-operated rats was evaluated on Kidney renin messenger RNA (mRNA) levels, tissue and plasma renin activity. Aorta coarctation or renal artery clipping transiently increased ischemic kidney renin mRNA 10- to 16-fold, which was insufficient to account for the 30- to 50-fold increase in plasma renin activity.

synapsesocial.com/papers/6a0ace899b4eb2f7ce2e1b4dhttps://doi.org/10.1161/01.hyp.8.10.874
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of renin-angiotensin system in chronic renal hypertensive rats.1979 · 52 citations
  2. 2Measurement of Renin Activity, Concentration and Substrate in Rat Plasma by Radioimmunoassay of Angiotensin I1972 · 455 citations
  3. 3Neural Stimulation of Release of Renin1966 · 231 citations
  4. 4EFFECTS OF ADRENALINE, NORADRENALINE, ISOPRENALINE AND SALBUTAMOL ON THE PRODUCTION AND RELEASE OF RENIN BY ISOLATED RENAL CORTICAL CELLS OF THE CAT1975 · 22 citations
  5. 5A Radioimmunoassay for the Direct Measurement of Renin in Mice and Its Application to Submaxillary Gland and Kidney Studies1974 · 96 citations